The drivers for Prolific chipset PL2303 have been known to malfunction under Windows 10 (and other versions of Windows). Although it may be possible to get them working using the latest Prolific drivers available here http://www.prolific.com.tw/US/
Here are a few of them:
https://www.amazon.com/s/ref=nb_sb_noss_1?url=search-alias%3Daps&field-keywords=usb+serial+ftdi
http://www.usconverters.com/index.php?main_page=index&cPath=67 (non Economy Mini versions)